This interaction should be given consideration in patients taking CELEBREX concomitantly with ACE-inhibitors. Because of its lack of platelet effects, CELEBREX is not a substitute for aspirin for cardiovascular prophylaxis. CELEBREX should be introduced at the lowest recommended dose in patients receiving fluconazole. Patients on lithium treatment should be closely monitored when CELEBREX is introduced or withdrawn.
However, in post-marketing experience, serious bleeding events, some of which were fatal, have been reported, predominantly in the elderly, in association with increases in prothrombin time in patients receiving CELEBREX concurrently with warfarin. Vioxx Fans Have Their Say Patients who rely on painkillers like Bextra and Celebrex are seeking more relief. Cox-2 Woes Fuel Drug Ad Debate Direct-to-consumer advertising of the cox-2 prescription painkillers Vioxx and Celebrex helped catapault worldwide sales of the drugs into the billions.